nitd008 (nr-36199) Search Results


nitd008 (nr-36199)  (BEI Resources)
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BEI Resources nitd008 (nr-36199)
Compound cytotoxicity for 53 candidate compounds and positive control <t>NITD008</t> (blue). Gray bars represent seven candidates with cytotoxicities of <1 (dashed horizontal bar). Compounds tested in triplicate at 25 μM.
Nitd008 (Nr 36199), supplied by BEI Resources, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Compound cytotoxicity for 53 candidate compounds and positive control NITD008 (blue). Gray bars represent seven candidates with cytotoxicities of <1 (dashed horizontal bar). Compounds tested in triplicate at 25 μM.

Journal: Biochemistry

Article Title: Identification of Zika Virus Inhibitors Using Homology Modeling and Similarity-Based Screening to Target Glycoprotein E

doi: 10.1021/acs.biochem.0c00458

Figure Lengend Snippet: Compound cytotoxicity for 53 candidate compounds and positive control NITD008 (blue). Gray bars represent seven candidates with cytotoxicities of <1 (dashed horizontal bar). Compounds tested in triplicate at 25 μM.

Article Snippet: NITD008 (NR-36199) was obtained through BEI Resources, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), as part of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA) program.

Techniques: Positive Control

Cell viability results for 53 candidate compounds compared to the positive control NITD008 (blue). The data were normalized to ZIKV-infected cells. Values over 1 signifies inhibition of ZIKV-induced cell killing. Candidates 14–43 tested at 10 μM, all other candidates and the control NITD008 tested at 25 μM. Each group ordered by activity from high to low. Green bars represent candidates with mean activity of >1.

Journal: Biochemistry

Article Title: Identification of Zika Virus Inhibitors Using Homology Modeling and Similarity-Based Screening to Target Glycoprotein E

doi: 10.1021/acs.biochem.0c00458

Figure Lengend Snippet: Cell viability results for 53 candidate compounds compared to the positive control NITD008 (blue). The data were normalized to ZIKV-infected cells. Values over 1 signifies inhibition of ZIKV-induced cell killing. Candidates 14–43 tested at 10 μM, all other candidates and the control NITD008 tested at 25 μM. Each group ordered by activity from high to low. Green bars represent candidates with mean activity of >1.

Article Snippet: NITD008 (NR-36199) was obtained through BEI Resources, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), as part of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA) program.

Techniques: Positive Control, Infection, Inhibition, Control, Activity Assay

TCID50 infectivity results for 53 candidate compounds compared to the positive control NITD008 (blue). Candidates 14 and 43 were tested at 10 μM; all of the other candidates and the NITD008 control were tested at 25 μM. Red bars represent candidates that inhibited infectivity to <0.6 (horizontal dotted line) in the TCID50 assay and >1.0 in the cell viability assay. Yellow bars represent candidates with TCID50 activity but not flagged as active in the cell viability assay. Candidates 5* and 52* did not yield results in the TCID50 assay.

Journal: Biochemistry

Article Title: Identification of Zika Virus Inhibitors Using Homology Modeling and Similarity-Based Screening to Target Glycoprotein E

doi: 10.1021/acs.biochem.0c00458

Figure Lengend Snippet: TCID50 infectivity results for 53 candidate compounds compared to the positive control NITD008 (blue). Candidates 14 and 43 were tested at 10 μM; all of the other candidates and the NITD008 control were tested at 25 μM. Red bars represent candidates that inhibited infectivity to <0.6 (horizontal dotted line) in the TCID50 assay and >1.0 in the cell viability assay. Yellow bars represent candidates with TCID50 activity but not flagged as active in the cell viability assay. Candidates 5* and 52* did not yield results in the TCID50 assay.

Article Snippet: NITD008 (NR-36199) was obtained through BEI Resources, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), as part of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA) program.

Techniques: Infection, Positive Control, Control, TCID50 Assay, Viability Assay, Activity Assay

X – Y scatter plot defining activity from cell viability (>1.0 cutoff) and TCID50 (<0.6 cutoff) assays. Compounds colored red ( 8 , 15 , 30 , 36 , 41 , and 43 ) and blue (NITD008 control) were active in both assays. Compounds colored green ( 11 , 17 , 22 , and 27 ) or yellow ( 2 and 49 ) were active in one assay.

Journal: Biochemistry

Article Title: Identification of Zika Virus Inhibitors Using Homology Modeling and Similarity-Based Screening to Target Glycoprotein E

doi: 10.1021/acs.biochem.0c00458

Figure Lengend Snippet: X – Y scatter plot defining activity from cell viability (>1.0 cutoff) and TCID50 (<0.6 cutoff) assays. Compounds colored red ( 8 , 15 , 30 , 36 , 41 , and 43 ) and blue (NITD008 control) were active in both assays. Compounds colored green ( 11 , 17 , 22 , and 27 ) or yellow ( 2 and 49 ) were active in one assay.

Article Snippet: NITD008 (NR-36199) was obtained through BEI Resources, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), as part of the World Reference Center for Emerging Viruses and Arboviruses (WRCEVA) program.

Techniques: Activity Assay, Control